第二代游戏仍然扮演来自前作的自定义英雄，同时引入了名为“圣安德列斯风格”的升级系统。并且该作取消在线多人模式，支持合作模式。

游戏一共包含5个职业，狂枪手、刺客、魔女、突击兵以及械操控手。如果你对这些角色的外观或技能都不满意的话，也能透过Quick Change Machine去变更操控角色的长相，或是花点钱去重新分配技能点数。 Shoot 'n' loot your way through this critically acclaimed role-playing adventure while you're on the move.

Play as one of six vault hunters and choose your own unique combination of skills and weapons as you fight wild beasts, marauding psychos and the evil mastermind, Handsome Jack.

Team up with a friend as you raid the furthest reaches of the unpredictable living planet Pandora and get more bang for your buck with these bonus downloadable content packs included: